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KMID : 1024320220120010064
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Journal of the Korean Dysphagia Society
2022 Volume.12 No. 1 p.64 ~ p.69
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Atypical Dysphagia in an Anti-Hu Positive Non-Small-Cell Lung Cancer Patient
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Kim In-Ah
Kim Jea-Na
Lee Hee-Yeon
Park Geun-Young
Jeong Sang-Ah
Hwang Hye-Mi
Im Sun
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Abstract
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Anti-Hu antibodies usually present in small cell lung cancer are associated with encephalomyelitis, encephalitis, cerebellitis, and neuropathies. However, to our knowledge, non-small-cell lung cancer (NSCLC) related anti-Hu syndrome presenting acute exacerbation of dysphagia has not been reported. Herein, we report a rare case of atypical dysphagia in an anti-Hu positive NSCLC patient resulting in a fatal outcome. A 73-year-old Korean male went through surgical interventions for recurrent tongue cancer and NSCLC. After the surgery, he resumed full oral feeding with a regular diet. However, four weeks later, he developed a sudden difficulty in swallowing. Neck computed tomography angiography, brain magnetic resonance imaging, brain positron emission tomography, computed tomography and electromyography all showed nonspecific findings. A paraneoplastic antibody test was positive for anti- Hu antibodies. His dysphagia worsened and eventually, he expired due to malignant pleural effusion. Our case shows that anti-Hu antibodies can be expressed in NSCLC and when associated with dysphagia, the outcome can be fatal.
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KEYWORD
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Deglutition disorders, Paraneoplastic syndromes, Carcinoma, Non-small-cell lung
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